Pharmacokinetics determines how the body interacts with drugs in the process of absorption, distribution, metabolism, and excretion. This presentation will review these four processes, focusing on the key steps in each and the impact of certain disease states and other drugs or foods on pharmacokinetics.
In the second half of this presentation, an exploration into pharmacogenomics explains how each individual may have unique drug responses based on genetic variability in certain aspects of pharmacokinetic ability, particularly metabolism and excretion. These responses may affect drug efficacy or may predict adverse outcomes.
Included in this session are the following considerations:
- Enterohepatic circulation in the metabolism of drugs
- Variability of drug responses related to gender or age
- Cytochrome P450 and drug interactions
- Pregnancy and pediatric populations