Pharmacokinetics and Pharmacogenomics

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The process of pharmacokinetics describes how the body interacts with drugs, including absorption, distribution, metabolism and excretion.  All of these play a major role in drug selection and outcomes.  In this presentation, the learner will review these four processes, focusing on key steps in each, and the impact of factors such as age, certain disease states, other drugs, foods, and gender on pharmacokinetics.  Pharmacogenomics examines how each individual may have unique drug responses based on genetic variability in certain aspects of pharmacokinetic ability—particularly metabolism and excretion.  These responses may affect drug efficacy or may predict adverse outcomes.  Because of pharmacogenomics, testing for metabolic capability is currently being recommended prior to prescribing certain drugs.  The future utility of pharmacogenomics as a clinical science to ensure safe prescribing is also addressed.

Included in this talk is information on:

  • The four aspects of pharmacokinetics including absorption, distribution, metabolism and excretion, and how these impact drug selection across the lifespan

  • Factors that influence pharmacokinetic parameters such as hepatic and renal disease, decreased absorptive capacity, route of administration, impaired blood flow, variability in metabolizing enzyme activity, drugs, certain foods, gender and age

  • The importance and clinical relevance of pharmacogenomics as it pertains to drugs known to cause adverse effects or to have a narrow therapeutic index

  • Relative differences between the cytochrome P450 metabolic enzyme subclasses in the liver and their contribution to pharmacogenomics differences among patient populations