This presentation examines the physiologic changes that make the elderly vulnerable to adverse drug outcomes, as well the drugs most likely to cause such problems. Drugs on the Beers list that are most associated with a high risk of adverse effects are also reviewed. Over-the-counter and herbal preparations that are known to interact with prescription medications and pose a risk for polypharmacy are discussed, as are means to handle this issue with patients. Treatment of common problems in the elderly, including osteoarthritis, benign prostatic hypertrophy, dementia, insomnia, hypertension, and coagulopathies are addressed, along with drugs of abuse in this population.

• Physiological changes that make the elderly vulnerable to adverse drug outcomes

• Drugs on the Beers list that are most associated with a high risk of adverse effects

• Treatment of common problems in the elderly